Thermo Fisher Scientific KCNE1L Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:300–1:2,000
• Publications: Reference Available

Immunohistochemistry (IHC)

• Tested Dilution: 1:300–1:2,000
• Publications: Reference Available

Miscellaneous PubMed (Misc)

• Publications: View 1 publication

Product Specifications

Product Specific Information

• Reconstitute in 100 µL of sterile water.
• Centrifuge to remove any insoluble material.
• Specificity: KCNE1L.

Target Information

Kcne1 is a member of voltage-gated potassium (Kv) channels, representing one of the most complex classes of voltage-gated ion channels in terms of function and structure. Kv channels are involved in diverse physiological processes such as:

• Neurotransmitter release
• Heart rate regulation
• Insulin secretion
• Neuronal excitability
• Epithelial electrolyte transport
• Smooth muscle contraction
• Cell volume control

The Kcne1 gene encodes a membrane protein similar to the KCNE1 gene product, part of the isk-related subfamily of potassium channels. It is an intronless gene deleted in AMME contiguous gene syndrome and may contribute to cardiac and neurological abnormalities associated with this syndrome. Functionally, Kcne1 acts as a potassium channel ancillary subunit, forming heteromeric complexes with Kv channel alpha subunits to generate native K(+) currents. It also serves as an inhibitory beta-subunit of the repolarizing cardiac potassium ion channel KCNQ1.

Diseases associated with KCNE1 include:

• Jervell and Lange-Nielsen Syndrome 2
• Long QT Syndrome 5

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.