Thermo Fisher Scientific SPHK2 Polyclonal Antibody
SPHK2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 ELISA에 사용 가능. HEK-293 세포를 양성 대조군으로 권장. 암 연구 및 세포 신호 전달 관련 연구용으로 적합.
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: Assay-dependent
ELISA
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to the N-terminal extension of Sphk2-L |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Ammonium sulfate precipitation |
| Storage buffer | PBS |
| Contains | 0.08% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1087454 |
Product Specific Information
- A suggested positive control for this product is HEK-293 cells.
Target Information
SPHK2, along with SPHK1, catalyzes the phosphorylation of sphingosine producing the signaling molecule sphingosine-1-phosphate (S1P).
S1P signals through G-protein coupled receptors and controls diverse cellular processes.
Inhibitors of SPHKs are viewed as potential therapeutics for the treatment of cancer.
SPHK2 plays key roles in regulating cell differentiation, calcium mobilization, and apoptosis.
S1P receptors (EDG family) couple to multiple G proteins and regulate cell motility, survival, migration, and interaction.
S1P is also involved in cardiogenesis, vascular maturation, oocyte survival, immune cell trafficking, and neuronal and bone cell regulation.
S1P levels are controlled by the activity of Sphk1 and Sphk2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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