Thermo Fisher Scientific Bcl-2 Polyclonal Antibody
Thermo Fisher Scientific의 Bcl-2 Polyclonal Antibody는 인간, 마우스, 랫트에 반응하는 Rabbit IgG 기반 항체로 Western blot 및 IHC 등 다양한 응용에 적합합니다. 0.2 mg/mL 농도의 액상 제품이며, PBS + 0.2% gelatin buffer에 보관됩니다. 세포 사멸 조절 연구에 이상적입니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:200 | View 1 publication |
| Immunohistochemistry (IHC) | - | View 4 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | - | View 2 publications |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent | - |
| Immunoprecipitation (IP) | Assay-dependent | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide (Human, N-terminal) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 0.2% gelatin |
| Contains | 0.1% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Wet ice |
| RRID | AB_2064294 |
Product Specific Information
Suggested positive controls for this product are HL-60 and Jurkat.
Target Information
BCL-2 is a key regulator of apoptosis that functions to either inhibit or promote cell death. Members of the BCL-2 family dimerize to modulate apoptosis.
- Bag1 forms a heterodimer with BCL-2, enhancing its anti-apoptotic effect.
- Bax and Bak promote cytochrome c release from mitochondria, initiating apoptosis.
Constitutive expression of BCL-2, often due to translocation to the Ig heavy chain locus, is associated with follicular lymphoma.
In most follicular lymphomas, neoplastic germinal centers express high levels of BCL-2 alpha protein, while normal or hyperplastic centers are negative.
Two transcript variants of BCL-2 differ in their C-terminal ends. Overexpression of BCL-2 has been linked to human cancers such as B-cell lymphoma and prostate cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: PA1-30411_BCL-2_P10415-1_Rabbit.svg, PA1-30411_BCL-2_P10415-1_Rabbit_PDP.jpeg)
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