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Thermo Fisher Scientific p21 Polyclonal Antibody
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Thermo Fisher Scientific p21 Polyclonal Antibody

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p21 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, IP 등 다양한 응용 가능. 인간, 마우스, 랫트 반응성. 액상 형태, PBS+gelatin buffer 포함. 종양 억제 단백질 연구용에 적합.

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pk
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마지막 업데이트 2025. 08. 04. 오후 04:21
Thermo Fisher Scientific PA130399 p21 Polyclonal Antibody 1 mL pk판매 단위 pk ·
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831,900원VAT 포함 915,090원

Thermo Fisher Scientific · Thermo Fisher Scientific p21 Polyclonal Antibody

Applications

Application Tested Dilution Publications
Western Blot (WB) 1:200 View 2 publications
Immunohistochemistry (Paraffin) (IHC (P)) - View 1 publication
Immunohistochemistry (Frozen) (IHC (F)) Assay-dependent View publication
Immunoprecipitation (IP) Assay-dependent View 1 publication

Product Specifications

Specification Description
Species Reactivity Human, Mouse, Rat
Published Species Mouse
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen Synthetic peptide (Human, C terminal)
Conjugate Unconjugated
Form Liquid
Concentration 0.2 mg/mL
Purification Affinity chromatography
Storage Buffer PBS with 0.2% gelatin
Contains 0.1% sodium azide
Storage Conditions 4°C, do not freeze
Shipping Conditions Wet ice
RRID AB_2291544

Product Specific Information

Recommended positive control: C32 cell line.


Target Information

Protein p21 is a tumor suppressor protein that inhibits Cyclin-dependent kinases (CDK) and is transcriptionally activated by p53.
It plays a key role in the cellular response to genotoxic stress and is a major transcriptional target of the p53 protein.

  • In the nucleus, p21 binds and inhibits Cdk1 and Cdk2, blocking the transition from G1 to S phase or from G2 to mitosis after DNA damage, allowing DNA repair.
  • In the cytoplasm, p21 has anti-apoptotic effects by inhibiting caspase 3, ASK1, and JNK.
  • p21 exhibits dual functions in carcinogenesis, acting both as a tumor suppressor and as an oncogene depending on cellular context.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.


제품 이미지

(이미지: PA1-30399_p21_P38936-1_Rabbit.svg, PA1-30399_p21_P38936-1_Rabbit_PDP.jpeg)

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