Thermo Fisher Scientific p21 Polyclonal Antibody
p21 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, IP 등 다양한 응용 가능. 인간, 마우스, 랫트 반응성. 액상 형태, PBS+gelatin buffer 포함. 종양 억제 단백질 연구용에 적합.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:200 | View 2 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | - | View 1 publication |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent | View publication |
| Immunoprecipitation (IP) | Assay-dependent | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide (Human, C terminal) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 0.2% gelatin |
| Contains | 0.1% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Wet ice |
| RRID | AB_2291544 |
Product Specific Information
Recommended positive control: C32 cell line.
Target Information
Protein p21 is a tumor suppressor protein that inhibits Cyclin-dependent kinases (CDK) and is transcriptionally activated by p53.
It plays a key role in the cellular response to genotoxic stress and is a major transcriptional target of the p53 protein.
- In the nucleus, p21 binds and inhibits Cdk1 and Cdk2, blocking the transition from G1 to S phase or from G2 to mitosis after DNA damage, allowing DNA repair.
- In the cytoplasm, p21 has anti-apoptotic effects by inhibiting caspase 3, ASK1, and JNK.
- p21 exhibits dual functions in carcinogenesis, acting both as a tumor suppressor and as an oncogene depending on cellular context.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지: PA1-30399_p21_P38936-1_Rabbit.svg, PA1-30399_p21_P38936-1_Rabbit_PDP.jpeg)
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