Thermo Fisher Scientific APEX1 Monoclonal Antibody (OTI1H9), TrueMAB
Thermo Fisher Scientific의 APEX1 단클론 항체(OTI1H9)는 인간 및 개 시료에 반응하며 Western blot과 IHC에 최적화된 고품질 항체입니다. Human APEX1 단백질(aa 1–242)을 면역원으로 사용하였으며, 액상 형태로 1 mg/mL 농도, PBS/BSA/glycerol 버퍼에 보관됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Dog, Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1H9 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–242 of human APEX1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Mammalian apurinic/apyrimidinic endonuclease (APE/ref-1) is a multifunctional, bipartite enzyme that plays an important role in numerous cellular functions.
APE is responsible for repairing abasic sites in DNA and regulating the redox state of proteins involved in oxidative signaling, transcription factor regulation (Fos, Jun, NF-kB, Myb, HIF-1α, CREB, Pax), cell cycle control (p53), and apoptosis.
Abasic sites arise through spontaneous loss or oxidative DNA damage, chemically initiated hydrolysis, ionizing radiation, UV irradiation, oxidizing agents, and removal of modified bases by DNA glycosylases.
APE expression varies during development and across tissues, with diverse subcellular localization supporting interactions with other cellular proteins beyond nuclear DNA repair.
Regulation of APE by phosphorylation is mediated partly by casein kinase II.
Increases in APE message and protein levels are observed upon reoxygenation of hypoxic cells and in certain malignant tissues, while decreases are associated with apoptosis induction.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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