Thermo Fisher Scientific APEX1 Monoclonal Antibody (OTI6E10), TrueMAB
APEX1 단백질을 표적으로 하는 Mouse IgG2a 단클론 항체로, WB, IHC, ICC, Flow Cytometry 등 다양한 응용에 적합. 고순도 Affinity chromatography 정제, PBS/BSA/glycerol buffer 저장. DNA 손상 복구 및 산화 신호 조절 연구용.
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Thermo Fisher Scientific APEX1 Monoclonal Antibody (OTI6E10), TrueMAB
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI6E10 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–242 of human APEX1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Mammalian apurinic/apyrimidinic endonuclease (APE/ref-1) is a multifunctional enzyme involved in DNA repair and redox regulation of other proteins related to oxidative signaling and transcription factor regulation (Fos, Jun, NF-κB, Myb, HIF-1α, CREB, Pax), cell cycle control (p53), and apoptosis.
APE repairs abasic sites in DNA caused by spontaneous loss, oxidative damage, chemical hydrolysis, ionizing radiation, UV irradiation, or removal of modified bases by DNA glycosylases.
It is differentially expressed across tissues and developmental stages, with diverse subcellular localization patterns supporting interactions with multiple cellular proteins.
Regulation of APE by phosphorylation is mediated by casein kinase II. Increased APE levels are observed upon reoxygenation of hypoxic cells and in certain malignant tissues, while decreased expression is associated with apoptosis induction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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