Thermo Fisher Scientific CaMKII alpha Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:500–1:2,000

Product Specifications

Product Specific Information

• Preservative-free formulation.
• To prevent contamination, add sodium azide (final concentration 0.05%–0.1%).
• Specificity: Human CaMKII alpha (CAMK2A).

Target Information

CAMK2A (CaMKII alpha) is a serine/threonine kinase that regulates various cellular functions such as neuronal signaling, gene expression, carbohydrate metabolism, cytoskeletal organization, and calcium homeostasis.
Autophosphorylation at threonine 286 activates CAMK2A, enabling calmodulin-independent activity.
CaMKII is widely expressed and plays roles in:

• Cell cycle and transcription regulation
• Dendritic spine and synapse formation
• Neuronal plasticity
• Sarcoplasmic reticulum Ca²⁺ transport in skeletal muscle
  In neurons, it contributes structurally to actin cytoskeleton reorganization during plasticity by binding and bundling actin filaments independent of kinase activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 파일명: PA5-81149_CaMKII_alpha_Q9UQM7-1_Rabbit.svg, PA5-81149_CaMKII_alpha_Q9UQM7-1_Rabbit_PDP.jpeg)