Thermo Fisher Scientific LPHN1 Polyclonal Antibody
Rabbit polyclonal antibody targeting human LPHN1 (Adgrl1). Validated for IHC (paraffin) at 20 µg/mL. Recognizes multiple species including human, mouse, rat, and primate. Suitable for research on GPCR-mediated synaptic signaling and exocytosis.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 20 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Hamster, Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 16 amino acid peptide from C-terminus of human LPHN1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage conditions | Store at 4°C short term. For long term, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551272 |
Product Specific Information
Percent identity with other species by BLAST analysis:
Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster, Elephant, Platypus (100%)
Bat, Bovine, Horse, Pig, Opossum (94%)
Target Information
Adgrl1 (Latrophilin-1) is a calcium-independent receptor with high affinity for alpha-latrotoxin, a neurotoxin from black widow spider venom that induces massive exocytosis in neurons and neuroendocrine cells. It acts as a receptor for TENM2, mediating synaptic cell-cell contact and postsynaptic specialization, and may regulate exocytosis.
The Adgrl1 gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCRs), functioning in both cell adhesion and signal transduction. Proteolytic cleavage within the GPS (G-protein-coupled-receptor proteolysis site) domain produces two non-covalently bound subunits at the cell membrane.
Adgrl1 recruits alpha-latrotoxin to the synapse plasma membrane. Alternative splicing results in multiple isoforms.
Diseases associated with ADGRL1 include Dermatophytosis and Late-Onset Autosomal Dominant Retinal Degeneration.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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