Thermo Fisher Scientific LPHN1 Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested dilution: 8 µg/mL

Product Specifications

Target Information

Adgrl1 (Latrophilin-1) is a calcium-independent receptor with high affinity for alpha-latrotoxin, an excitatory neurotoxin from black widow spider venom that triggers massive exocytosis in neurons and neuroendocrine cells.
It acts as a receptor for TENM2, mediating heterophilic synaptic cell-cell contact and postsynaptic specialization, and may play a role in regulating exocytosis.
The Adgrl1 gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR), which function in both cell adhesion and signal transduction.
Endogenous proteolytic cleavage within the GPS (G-protein-coupled-receptor proteolysis site) domain produces two non-covalently bound subunits at the cell membrane.
Adgrl1 recruits alpha-latrotoxin to the synapse plasma membrane. Alternative splicing results in multiple isoforms.
Diseases associated with ADGRL1 include Dermatophytosis and Late-Onset Autosomal Dominant Retinal Degeneration.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.