Thermo Fisher Scientific STRAP Polyclonal Antibody
Human, Mouse, Rat에서 반응하는 STRAP 폴리클로날 항체로 Western blot 및 IHC(P) 검증 완료. 항원 친화 크로마토그래피로 정제된 액상 항체이며, 0.1 mg/mL 농도로 PBS(40% glycerol) 내 보존. TGF-β 신호 억제 및 세포 증식 조절 연구에 적합.
- 카탈로그번호
- PA555583
- 판매단위
- pk
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human STRAP. Recombinant protein control fragment (Product # RP-95094) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2648036 |
Product Specific Information
Immunogen sequence:
AFSGITPYGY FLISACKDGK PMLRQGDTGD WIGTFLGHKG AVWGATLNKD ATKAATAAAD FTAKVWDAVS GDELMTL
Sequence identity:
Mouse – 100%, Rat – 100%
Target Information
STRAP is a 350 amino acid MAP activator with WD-40 repeats localized in both cytoplasm and nucleus. It acts as an inhibitor of TGF-beta signaling and regulates cell proliferation. Stable expression of STRAP activates the MAPK/ERK pathway and downregulates p21 (Cip1), leading to retinoblastoma protein hyperphosphorylation. Upregulation of STRAP is associated with early tumorigenesis in colorectal cancers. It also plays a key role in U snRNP assembly with the SMN complex, influencing intracellular SMN1 distribution.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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