Thermo Fisher Scientific STAR Polyclonal Antibody
인간 StAR 단백질을 인식하는 토끼 다클론 항체로, IHC(P)에서 1:50–1:200 희석으로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS(40% 글리세롤) 버퍼에 0.02% 아지드 포함. 4°C 단기, -20°C 장기 보관 권장. 연구용 전용.
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Applications
Tested Applications and Dilutions
- Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human STAR. Recombinant protein control fragment (Product #RP-93804) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2647995 |
Product Specific Information
Immunogen sequence:
TCVLAGMATD FGNMPEQKGV IRAEHGPTCM VLHPLAGSPS KTKLTWLLSI DLKGWLPKSI INQVLSQTQV DFAN
Sequence identity:
- Mouse: 92%
- Rat: 91%
Target Information
Steroidogenic acute regulatory protein (StAR) plays a significant role in cholesterol transport from the cytoplasmic outer membrane to the inner mitochondrial membrane.
The 37 kDa precursor is cleaved to generate an active 28 kDa protein capable of facilitating cholesterol metabolism into pregnenolone.
StAR is prevalently expressed in mitochondria of steroid-producing adrenal and gonadal tissue.
Abnormalities in StAR gene expression are associated with autosomal Lipoid Congenital Adrenal Hyperplasia (LCAH), resulting in defects in pregnenolone and cortisol synthesis.
The mechanism of cholesterol binding to StAR has yet to be elucidated.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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