Thermo Fisher Scientific PI3K type III Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Store vial at -20°C prior to opening.
• Aliquot contents and freeze at -20°C or below for extended storage.
• Avoid cycles of freezing and thawing.
• Centrifuge product if not completely clear after standing at room temperature.
• Stable for several weeks at 4°C as an undiluted liquid.
• Dilute only prior to immediate use.

A BLAST analysis suggests cross-reactivity with mouse and human based on 100% sequence homology.
Cross-reactivity with PI3K, type III from other sources has not been determined.

Target Information

PIKFYVE belongs to a large family of lipid kinases that alter the phosphorylation status of intracellular phosphatidylinositol. The content of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) in endosomal membranes changes dynamically with fission and fusion events that generate or absorb intracellular transport vesicles.
PIKFYVE is the PtdIns(3,5)P2-producing component of a trimolecular complex that regulates the level of PtdIns(3,5)P2. Other components include the PIKFYVE activator VAC14 and the PtdIns(3,5)P2 phosphatase FIG4.
In addition to its phosphoinositide 5-kinase activity, PIKFYVE also has protein kinase activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.