Thermo Fisher Scientific PI3K type III Polyclonal Antibody
PI3K type III 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot, ELISA, IP에 적합합니다. Human 시료에 반응하며, Affinity chromatography로 정제되었습니다. -20°C에서 보관하며, 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Anti-PI3K, type III affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to the C-terminal region of human PI3K, type III protein. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.02 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.02M potassium phosphate, pH 7.2, with 0.15M NaCl, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Store vial at -20°C prior to opening.
- Aliquot contents and freeze at -20°C or below for extended storage.
- Avoid cycles of freezing and thawing.
- Centrifuge product if not completely clear after standing at room temperature.
- Stable for several weeks at 4°C as an undiluted liquid.
- Dilute only prior to immediate use.
A BLAST analysis suggests cross-reactivity with mouse and human based on 100% sequence homology.
Cross-reactivity with PI3K, type III from other sources has not been determined.
Target Information
PIKFYVE belongs to a large family of lipid kinases that alter the phosphorylation status of intracellular phosphatidylinositol. The content of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) in endosomal membranes changes dynamically with fission and fusion events that generate or absorb intracellular transport vesicles.
PIKFYVE is the PtdIns(3,5)P2-producing component of a trimolecular complex that regulates the level of PtdIns(3,5)P2. Other components include the PIKFYVE activator VAC14 and the PtdIns(3,5)P2 phosphatase FIG4.
In addition to its phosphoinositide 5-kinase activity, PIKFYVE also has protein kinase activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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