Thermo Fisher Scientific Peptidylarginine Deiminase Polyclonal Antibody
Peptidylarginine Deiminase 단백질을 인식하는 Rabbit Polyclonal 항체. Western blot, IHC(P), ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS와 50% glycerol에 보관. 연구용으로만 사용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.5–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5–20 µg/mL |
| Immunocytochemistry (ICC/IF) | 5–20 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein Peptidyl Arginine Deiminase Type I (amino acids 298–556 of the target protein) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2903831 |
Target Information
This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type I enzyme is involved in the late stages of epidermal differentiation, where it deiminates filaggrin and keratin K1, maintaining hydration of the stratum corneum and the cutaneous barrier function. It may also play a role in hair follicle formation. This gene exists in a cluster with four other paralogous genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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