Thermo Fisher Scientific CD223 Recombinant Rat Monoclonal Antibody (C9B7W)
Thermo Fisher Scientific의 CD223 Recombinant Rat Monoclonal Antibody (C9B7W)는 마우스 LAG-3 단백질의 D2 도메인 특이 항체입니다. Flow Cytometry, IP, Inhibition Assay 등 다양한 응용에 적합하며, HEK293 발현 시스템에서 생산된 고순도 단백질 A 정제 항체입니다. 연구용으로만 사용됩니다.
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Applications
Flow Cytometry (Flow)
- Tested Dilution: Assay-dependent
Immunoprecipitation (IP)
- Tested Dilution: Assay-dependent
Inhibition Assays (IA)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rat / IgG1, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | C9B7W |
| Immunogen | This antibody was raised by immunising Lewis rats with a murine LAG-3:Ig fusion protein. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074656 |
Product Specific Information
Specificity: This antibody is specific for an epitope in the D2 domain of murine LAG-3.
Target Information
LAG-3 is a 70-kDa surface glycoprotein belonging to the Ig superfamily with homology to CD4.
LAG-3 binds to MHC class II with higher affinity than CD4 and is thought to be involved in the negative regulation of T cell activation and homeostatic proliferation.
Surface expression of LAG-3 has been reported on activated T cells (including regulatory T cells) and NK cells.
CD8+ T cells usually express LAG-3 at significantly higher levels than CD4+ T cells.
Coexpression of LAG-3 and CD49b has been proposed to identify human and mouse Type 1 regulatory T cells (Tr1 cells).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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