Thermo Fisher Scientific KREMEN2 Polyclonal Antibody
Human 및 Mouse 시료에 반응하는 Rabbit Polyclonal 항체로, Western Blot과 Immunocytochemistry에 사용 가능. KREMEN2 단백질의 C-말단 영역을 면역원으로 제작. 항원 친화 크로마토그래피로 정제된 액상 형태. Wnt 신호 조절 연구 및 골 재형성 관련 연구에 적합.
- 카탈로그번호
- PA534525
- 판매단위
- pk
카탈로그
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunocytochemistry (ICC/IF) | 5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A peptide corresponding to 14 amino acids near the carboxy terminus of human KREMEN2 (amino acids 390–440). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551877 |
Product Specific Information
- Suggested positive control: Hela cell lysate
- PA5-34525 can be used with blocking peptide PEP-1568.
Target Information
Kremen (Kringle containing protein marking the eye and the nose) proteins are type I transmembrane proteins that contain extracellular kringle, WSC, and CUB domains and an intracellular region without conserved motifs.
Kremens bind a subset of secreted Dickkopf proteins (Dkk 1, 2, and 4) with high affinity to modulate the canonical Wnt signaling pathway via the ternary receptor complex of Wnt, Frizzled, and LRP5/6 co-receptor.
Recent studies indicate that KREMEN2 regulates bone remodeling and may be a therapeutic target for bone loss disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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