Thermo Fisher Scientific Furin VHH-8His-Cys-tag Recombinant Alpaca Monoclonal Antibody (SAA1044)
Thermo Fisher Scientific의 Furin VHH-8His-Cys-tag 재조합 알파카 단일클론 항체(SAA1044)는 인간 Furin 단백질을 인식하는 VHH형 항체입니다. CHO 세포에서 발현되며 ELISA에 적합합니다. 금속 킬레이트 크로마토그래피로 정제되었으며, PBS 용액 상태로 제공됩니다.
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Applications
- ELISA (ELISA): Assay-dependent
- Compatible with Direct ELISA
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Alpaca / VHH |
| Expression System | CHO cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SAA1044 |
| Immunogen | Recombinant Human FURIN |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Metal-chelate chromatography |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
Product Specific Information
- Compatible with Direct ELISA
Target Information
Furin is a membrane-associated, calcium-dependent serine protease belonging to the subtilisin-like prohormone convertase (PC) family. These enzymes cleave most prohormones and neuropeptide precursors, as well as various cellular, viral, and bacterial proteins transported via the constitutive secretory pathway.
Furin and other PC family members share structural similarities, including:
- A heterogeneous ~10 kDa amino-terminal proregion
- A highly conserved ~55 kDa subtilisin-like catalytic domain
- A variable-length carboxyl-terminal domain
These enzymes become catalytically active after proregion cleavage within the appropriate cellular compartment. Furin is the only known PC with a transmembrane domain. Cleavage occurs at the carboxyl-terminus of the furin consensus sequence RX(K/R)R.
The acidic peptide sequence C771PSDSEEDEG780 localizes furin to the trans-Golgi network, and phosphorylation of serine residues in this region modulates intracellular routing. The tetrapeptide Y759KGL762 serves as a signaling domain for internalization from the cell surface.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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