Thermo Fisher Scientific ARHGEF3 Polyclonal Antibody, MaxPab

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG

Class

Polyclonal

Type

Antibody

Immunogen

ARHGEF3 (AAH99715, 1 a.a. approximately 324 a.a) full-length human protein. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:ARHGEF3,uniProtId:Q9NR81-1,ncbiNodeId:9606,antigenRange:1-526,antigenLength:526,antigenImageFileName:H00050650-B01P_ARHGEF3_Q9NR81-1_House_mouse.svg,antigenImageFileNamePDP:H00050650-B01P_ARHGEF3_Q9NR81-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: MKLPCLSSYD SYCSNQVAAK ALLDHKKQDH RVQDFLQRCL ESPFSRKLDL WNFLDIPRSR LVKYPLLLRE ILRHTPNDNP DQQHLEEAIN IIQGIVAEIN TKTGESECRY YKERLLYLEE GQKDSLIDSS RVVCCHGELK NNRGVKLHVF LFQEVLVITR AVTHNEQLCY QLYRQPIPVK DLLLEDLQDG EVRLGGSLRG AFSNNERIKN FFRVSFKNGS QSQTHSLQAN DTFNKQQWLN CIRQAKETVL CAAGQAGVLD SEGSFLNPTT GSRELQGETK LEQMDQSDSE SDCSMDTSEV SLDCERMEQT DSSCGNSRHG ESNV

Target Information

Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.