Thermo Fisher Scientific FDPS Monoclonal Antibody (1049CT13.1.4)
FDPS 단백질을 인식하는 Thermo Fisher Scientific의 단클론 항체로, Western blot에 최적화되어 있습니다. 인간 및 마우스 시료에 반응하며, Protein G로 정제된 액상 형태입니다. 연구용으로 콜레스테롤 및 이소프레노이드 생합성 관련 연구에 활용 가능합니다.
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- MA537752
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- pk
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Applications
- Western Blot (WB): 1:2,000–1:4,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1049CT13.1.4 |
| Immunogen | Recombinant protein of human FDPS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2897676 |
Target Information
The isoprene biosynthetic pathway supplies the cell with cholesterol, ubiquinone, and various nonsterol metabolites. The farnesylpyrophosphate synthetase (FDPS) enzyme catalyzes the formation of geranyl and farnesylpyrophosphate from isopentenylpyrophosphate and dimethylallyl pyrophosphate. Analysis of FDPS activity and protein in rat liver, accompanied by immunofluorescence and immunoelectron microscopy studies, demonstrated that FDPS is predominantly localized in peroxisomes. Liver tissue from patients with peroxisomal deficiency diseases such as Zellweger syndrome and neonatal adrenoleukodystrophy exhibit diminished FDPS activity and subsequent isoprenoid synthesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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