Thermo Fisher Scientific CD357 (AITR/GITR) Chimeric Recombinant Rabbit Monoclonal Antibody (YGITR 860.103.5)
마우스 GITR(AITR) 단백질을 인식하는 키메릭 재조합 토끼 단클론 항체. ICC/IF 및 유세포분석에 사용 가능. HEK293 세포에서 발현된 IgG kappa 형식의 항체로, 단백질 A로 정제됨. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| Flow Cytometry (Flow) | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | YGITR 860.103.5 |
| Immunogen | Mouse GITR |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074378 |
Product Specific Information
Specificity: This antibody binds to mouse GITR.
Target Information
Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), also called GITR or AITR, is a protein encoded by the TNFRSF18 gene in humans and mapped to 1p36.33. This receptor belongs to the TNF-receptor superfamily and shows increased expression upon T-cell activation. It plays a key role in maintaining immunological self-tolerance via CD25(+)CD4(+) regulatory T cells. Knockout studies in mice indicate its involvement in CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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