Thermo Fisher Scientific CD137 (TNFRSF9) Monoclonal Antibody (OTI12F12)

Applications

Western Blot (WB)

• Tested Dilution: 1:500

Flow Cytometry (Flow)

• Tested Dilution: 1:100

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

CD137 (TNFRSF9, also known as 4-1BB) is an inducible costimulatory molecule primarily expressed on activated T cells.
Its ligand, 4-1BBL, is expressed on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells.
CD137 signaling supports the survival and clonal expansion of activated and memory CD8+ T cells, while modulating myelopoiesis and dendritic cell development.
Activation of CD137 induces cytokine release that regulates peripheral monocyte survival. Soluble CD137 may act as a negative regulator of certain immune responses.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 없음)