Thermo Fisher Scientific Fibronectin Recombinant Rabbit Monoclonal Antibody (014)

Applications and Tested Dilution

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned and screened to select optimal candidates.
Advantages include:

• High specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulation
• Broad immunoreactivity due to the large rabbit immune repertoire

This antibody specifically recognizes Human Fibronectin Fragment 2.

Target Information

Fibronectin is a disulfide-bonded dimer (230–250 kDa) found in the extracellular matrix of connective tissues and vessels. It exists as insoluble, cross-linked polymers and as soluble plasma proteins.
Fibronectin plays critical roles in:

• Cell adhesion and migration
• Embryogenesis and wound healing
• Blood coagulation and host defense
• Cancer metastasis

Fibronectin expression is elevated in non-small cell lung carcinoma, where it enhances tumorigenicity and resistance to apoptosis induced by chemotherapeutic agents.
The gene encoding Fibronectin undergoes alternative splicing, producing up to 20 transcript variants, though not all full-length forms are characterized.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.