Thermo Fisher Scientific SKP1 Monoclonal Antibody (4E11)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

MA5-15928 targets SKP1 in indirect ELISA, FACS, IF, IHC, and WB applications, showing reactivity with human samples.
The immunogen is a purified recombinant fragment of human SKP1 expressed in E. coli.
MA5-15928 detects SKP1, which has a predicted molecular weight of approximately 19 kDa.

Target Information

This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins.
This protein binds directly to the F-box motif found in F-box proteins. SCF complexes are involved in the regulated ubiquitination of specific protein substrates, targeting them for degradation by the proteasome.
Specific F-box proteins recognize different target proteins, and many SCF substrates have been identified, including regulators of cell cycle progression and development.
Studies have also characterized this protein as an RNA polymerase II elongation factor.
Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.