Thermo Fisher Scientific RBL1 Monoclonal Antibody (OTI4E1), TrueMAB
RBL1 단백질을 표적으로 하는 Mouse IgG1 단클론 항체로 Western blot에 최적화됨. Human, Mouse, Rat 반응성. Lyophilized 형태로 제공되며, PBS buffer에 trehalose 포함. 연구용으로 세포주기 조절 관련 단백질 분석에 적합.
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Thermo Fisher Scientific RBL1 Monoclonal Antibody (OTI4E1), TrueMAB
Applications
- Western Blot (WB)
Tested Dilution: 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4E1 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 739–1014 of human RBL1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step.
Recommended product: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL (Product #89882)
Target Information
RB-like 1 (RBL1) shares sequence and functional similarity with the retinoblastoma 1 (RB1) gene product. RB1 acts as a tumor suppressor involved in cell cycle regulation, being phosphorylated during the S–M phase transition and dephosphorylated in the G1 phase.
Both RB1 and RBL1 can form complexes with adenovirus E1A and SV40 large T-antigen, with binding occurring only in the unphosphorylated form. These proteins inhibit transcription of cell cycle genes containing E2F binding sites, suggesting that RBL1 may also function as a tumor suppressor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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