Thermo Fisher Scientific EGFR Recombinant Rabbit Monoclonal Antibody (30H45L48), Alexa Fluor 555

Thermo Fisher Scientific EGFR Recombinant Rabbit Monoclonal Antibody (30H45L48), Alexa Fluor 555

Applications

• Immunocytochemistry (ICC/IF)

Tested Dilution: 1–10 µg/mL

Product Specifications

Additional Formats

• Unconjugated
• Alexa Fluor 488
• Alexa Fluor 647
• Request custom conjugation

Product Specific Information

This antibody is predicted to react with canine, mouse, and rat based on sequence homology.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.
Advantages include:

• Superior specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulation
• Broader immunoreactivity due to large rabbit immune repertoire

Target Information

EGFR (epidermal growth factor receptor) is a receptor tyrosine kinase that mediates signaling in response to various growth factors. Overexpression is associated with multiple cancer types and EGFR serves as a therapeutic target.
Encoded by the EGFR gene on chromosome 7, EGFR belongs to the HER/ERbB family (ERbB2, ERbB3, ERbB4). Ligand binding (e.g., EGF, TGF-α) induces receptor dimerization and autophosphorylation of cytoplasmic tyrosine residues.
Overexpression has been observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, and squamous cell carcinoma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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