Thermo Fisher Scientific CDKL2 Monoclonal Antibody (OTI5D9)
CDKL2 단백질을 인식하는 Mouse monoclonal 항체로, Western blot 및 IHC(P) 실험에 적합합니다. Human 시료에 반응하며, 고순도의 Affinity Chromatography 정제 항체입니다. PBS/BSA/glycerol buffer에 보관되며, -20°C에서 안정적으로 유지됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5D9 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 291–493 of CDKL2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2724118 |
Target Information
The activation of signal transduction pathways by growth factors, hormones, and neurotransmitters is mediated by the MAP kinases ERK1 and ERK2. These ERK proteins are regulated by dual phosphorylation at specific tyrosine and threonine residues within the Thr-Glu-Tyr motif.
The protein kinase p56 KKIAMRE is distantly related to the MAP kinase group and closely related to p42 KKIALRE. KKIAMRE is predominantly expressed in testis, kidney, brain, and lung. It contains the conserved MAP kinase dual phosphorylation motif (Thr-Asp-Tyr) and is activated by EGF treatment. Unlike other MAP kinases, EGF-stimulated kinase activity of KKIAMRE and KKIALRE does not require phosphorylation in the Thr-Asp-Tyr motif.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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