Thermo Fisher Scientific PPAR delta Polyclonal Antibody
PPAR delta 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody입니다. Western blot, IHC, IP 등 다양한 응용에 적합하며, Human, Mouse, Rat에 반응합니다. 항원 친화 크로마토그래피로 정제되었고, 고순도 액상 형태로 제공됩니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:3,000 | View 5 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 | - |
| Immunoprecipitation (IP) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to amino acids 129–378 of Human PPAR delta |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.44 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol, 1% BSA |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2547153 |
Product Specific Information
- Recommended positive controls: K562, HL-60, DDDDK-tagged PPARD delta-transfected 293T
- Predicted reactivity: Mouse (95%), Rat (94%), Japanese Medaka (80%), Dog (98%), Pig (95%), Rabbit (95%), Chicken (90%), Bovine (96%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate various biological processes and may be involved in the development of chronic diseases such as diabetes, obesity, atherosclerosis, and cancer.
PPAR delta is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. Expression is elevated in colorectal cancer cells and can be repressed by the tumor suppressor APC, associated with the APC/beta-catenin signaling pathway. Knockout studies in mice suggest roles in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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