Thermo Fisher Scientific CD207 (Langerin) Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 70-200 of human Langerin/CD207 (NP_0565324) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Langerin (CD207),uniProtId:Q9UJ71-1,ncbiNodeId:9606,antigenRange:70-200,antigenLength:328,antigenImageFileName:PA5-121010_Langerin_CD207_Q9UJ71-1_Rabbit.svg,antigenImageFileNamePDP:PA5-121010_Langerin_CD207_Q9UJ71-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.52 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2914582

Product Specific Information

Positive test controls include: A-549, A-431, Jurkat, Mouse lung, Rat lung, Rat liver. The target is usually found in the following locations: Membrane, Single-pass type II membrane protein.

Immunogen sequence: TISDVKTNVQ LLKGRVDNIS TLDSEIKKNS DGMEAAGVQI QMVNESLGYV RSQFLKLKTS VEKANAQIQI LTRSWEEVST LNAQIPELKS DLEKASALNT KIRALQGSLE NMSKLLKRQN DILQVVSQGW K

Target Information

Langerin (CD207) is a type II membrane-associated C-type lectin known to be expressed exclusively by Langerhans cells. Lamgerin recognizes mannose residues via its single carbohydrate recognition domain (CRD). Langerin is localized not only on the cell surface, but also intracellularly in close association with Birbeck granules. Transfection of Langerin cDNA into fibroblasts creates a compact network of membrane structures with typical features of Birbeck granules (BG). Langerin is thus a potent inducer of membrane superimposition and zippering leading to BG formation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.