Thermo Fisher Scientific MMP13 Monoclonal Antibody (OTI2F4), TrueMAB
Human MMP13 단백질(aa 104-471)에 특이적인 Mouse IgG1 단클론 항체. Western blot 및 Immunocytochemistry에 사용 가능. Lyophilized 형태로 제공되며, PBS와 trehalose buffer에 용해. 조직 재형성 및 골 발달 연구에 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1:4,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2F4 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 104–471 of human MMP13 produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
MMP13 (collagenase 3) is involved in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, tenascin C (TNC), and aggrecan (ACAN).
It cleaves triple helical collagens (types I, II, III) with highest activity on soluble type II collagen, and can degrade collagen types IV, XIV, and X.
MMP13 plays a critical role in wound healing, tissue remodeling, cartilage degradation, bone development, mineralization, and ossification.
Mutations in MMP13 can lead to skeletal dysplasias such as spondyloepimetaphyseal dysplasia Missouri type, metaphyseal anadysplasia 1, and metaphyseal dysplasia Sphar type.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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