Thermo Fisher Scientific ROR gamma Monoclonal Antibody (4G419)

Applications

Tested Dilution

Publications

Western Blot (WB)

5 µg/mL

View 1 publication 1 publication

Flow Cytometry (Flow)

0.25-0.5 µg per million cells

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

4G419

Immunogen

A portion of amino acids 1-50 of human ROR gamma if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:ROR gamma,uniProtId:P51449-1,ncbiNodeId:9606,antigenRange:1-50,antigenLength:518,antigenImageFileName:MA5-16227_ROR_gamma_P51449-1_House_mouse.svg,antigenImageFileNamePDP:MA5-16227_ROR_gamma_P51449-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.0 mg/mL

Purification

Protein A/G

Storage buffer

PBS

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2537745

Target Information

ROR gamma is a 560 amino acid novel DNA-binding transcription factor belonging to the ROR/RZR orphan nuclear receptor subfamily. Reports suggest thatROR gammais a ligand activated transcription factor and may be essential for lymphoid organogenesis (lymph nodes and Peyer`s patches) and may play an important regulatory role in controlling apoptosis during thymopoiesis. ROR gamma inhibits the expression of Fas ligand and IL2 and directs the differentiation program of proinflammatory IL-17+ T helper cells. ROR gamma shares 50 to 51% sequence identity with RORA and RORB and is 88% identical to mouse ROR gamma. It is highly expressed in skeletal muscle and at lower levels in various other tissues.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.