Thermo Fisher Scientific ASAH1 Polyclonal Antibody
ASAH1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, ICC 등 다양한 응용에 적합합니다. 인간, 마우스, 랫트 반응성이 있으며, 항원 친화 크로마토그래피로 정제된 액상 형태입니다. 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific ASAH1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | View 1 publication |
| Immunohistochemistry (IHC) | 2.5–5 µg/mL | - |
| Immunocytochemistry (ICC/IF) | 20 µg/mL | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | 16 amino acid peptide near the carboxy terminus of human ASAH1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Refrigerated at 2–8°C for up to 3 months; long-term at -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152325 |
Product Specific Information
- Suggested positive control: mouse heart tissue lysate
- PA5-20574 can be used with blocking peptide PEP-0694
Target Information
ASAH1 encodes a member of the acid ceramidase family of proteins. Alternative splicing results in multiple transcript variants, one of which encodes a preproprotein that is proteolytically processed into alpha and beta subunits forming the mature lysosomal enzyme. This enzyme catalyzes the degradation of ceramide into sphingosine and free fatty acid. It is overexpressed in multiple human cancers and may play a role in cancer progression.
Mutations in ASAH1 are associated with lysosomal storage disorder Farber lipogranulomatosis and neuromuscular disorder spinal muscular atrophy with progressive myoclonic epilepsy. Related pathways include Innate Immune System and Sphingolipid metabolism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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