Thermo Fisher Scientific Bombesin Receptor 3 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: Assay-dependent

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: Assay-dependent

Miscellaneous PubMed (Misc)

• View 1 publication

Product Specifications

Product Specific Information

• PA3-302 detects BRS3 from human samples.
• Successfully used in Western blot and immunohistochemistry (paraffin) procedures.
• By Western blot, detects a ~50–70 kDa protein representing BRS3.
• Immunogen: synthetic peptide corresponding to residues E(381) I S V T S F T G C S V K Q A E D R F(399) of human BRS3 protein.

Target Information

BRS3 expression has been reported in lung (normal and cancer), nasal mucosa, placenta, and uterus. ESTs have been isolated from normal brain and kidney cancer libraries.
G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices and exist in both active and inactive forms.
An array of activating ligands participate in the conformation of GPCRs leading to signaling via G-proteins and downstream effectors. Studies have shown reactions involved in the negative regulation of GPCRs, which have significant implications for cellular physiology and pharmacological research.
Two GPCR-targeted drugs, Zyprexa (Eli Lilly) and Claritin (Schering-Plough), have achieved multi-billion dollar success in mental health and allergy markets.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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