Thermo Fisher Scientific CCR5 Polyclonal Antibody
Rabbit polyclonal antibody targeting human CCR5, validated for Western blot. Recognizes amino acids 300–350 of CCR5. Suitable for HIV research. Supplied as liquid, 0.5 mg/mL in PBS with BSA and sodium azide. For research use only.
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Applications
Western Blot (WB)
- Tested Dilution: 1–3 µg/mL
- View 2 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 300–350 of human CCR5 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long-term, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2072680 |
Product Specific Information
- Suggested positive control: MCF-7 whole cell lysates.
Target Information
Human immunodeficiency virus (HIV) and related viruses require coreceptors, in addition to CD4, to infect target cells. Several G protein-coupled receptors, including CCR5, CXCR4, CCR3, CCR2b, and CCR8, act as HIV coreceptors. Among them, CCR5 (CC-CKR-5) is the principal coreceptor for macrophage- and dual-tropic HIV-1 strains, mediating fusion and entry into human white blood cells.
CCR5 is essential for infection by HIV-1, HIV-2, and SIV. The beta-chemokines RANTES, MIP-alpha, and MIP-beta are ligands for CCR5 and inhibit infection by M-tropic HIV-1. CCR5 interacts with the surface CD4-gp120 complex of HIV, facilitating membrane fusion and viral entry. The amino-terminal domain and extracellular loops of CCR5 serve as HIV binding sites. CCR5 mRNA is expressed in lymphoid organs and monocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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