Thermo Fisher Scientific ZNF198 Polyclonal Antibody
ZNF198 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, IP 등 다양한 응용 가능. Human 반응성 확인, Mouse 및 Orangutan 예측 반응성. 항원 친화 크로마토그래피로 정제된 고품질 연구용 항체.
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Thermo Fisher Scientific ZNF198 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:2,000 |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1327 and 1377 of Human zinc finger protein 198 (ZMYM2, UniProt ID: Q9UBW7-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- For IHC, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections
- Based on 100% sequence identity, this antibody is predicted to react with Mouse and Orangutan
Target Information
ZNF198 is a ubiquitously expressed nuclear protein whose physiological role is largely unknown. It contains:
- 5 N-terminal zinc finger motifs for protein-protein interactions
- A central proline-rich domain
- C-terminal nuclear localization signal (NLS) and acidic domain
A reciprocal chromosomal translocation involving ZNF198 and FGFR1 produces the ZNF198/FGFR1 fusion kinase, a ligand-dependent, constitutively active cytoplasmic tyrosine kinase. This fusion protein regulates STAT transcription factors (STAT1, STAT3, STAT5) and is associated with atypical myeloproliferative disease, peripheral blood eosinophilia, and T-cell leukemia/lymphoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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