Thermo Fisher Scientific ZNF198 Polyclonal Antibody
Rabbit Polyclonal Antibody against Human ZNF198, validated for WB, IHC, IHC(P), and IP. Recognizes residues 1327–1377 of ZMYM2 protein. Unconjugated liquid form, 0.20 mg/mL concentration. Recommended storage at 4°C, shelf life 1 year.
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Applications and Tested Dilutions
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 | |
| Immunohistochemistry (IHC) | 1:500–1:2,000 | |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:2,000 | |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1327 and 1377 of Human zinc finger protein 198 (ZMYM2, UniProt ID: Q9UBW7-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- For IHC, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections
- Based on 100% sequence identity, this antibody is predicted to react with Mouse and Orangutan
Target Information
ZNF198 is a ubiquitously expressed nuclear protein with largely unknown physiological roles. It contains:
- 5 N-terminal zinc finger motifs for protein-protein interactions
- A central proline-rich domain
- C-terminal nuclear localization signal (NLS) and acidic domain
A reciprocal chromosomal translocation involving ZNF198 and FGFR1 produces the ZNF198/FGFR1 fusion kinase, a ligand-dependent, constitutively active cytoplasmic tyrosine kinase. This fusion regulates STAT transcription factors (STAT1, STAT3, STAT5) and is oncogenic, associated with atypical myeloproliferative disease, peripheral blood eosinophilia, and T-cell leukemia/lymphoma.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
제품 이미지
(이미지 파일명: A301-711A-M_ZMYM2_Q9UBW7-1_Rabbit.svg, A301-711A-M_ZMYM2_Q9UBW7-1_Rabbit_PDP.jpeg)
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