Thermo Fisher Scientific CRALBP Recombinant Rabbit Monoclonal Antibody (HL1834)
CRALBP 단백질을 인식하는 Recombinant Rabbit Monoclonal Antibody로 인간과 마우스 시료에 반응. Western blot에 최적화된 고순도 단백질 A 정제 항체. 시각색소 재생 관련 연구 및 RPE, Müller glial cell 마커로 활용 가능.
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Applications
- Western Blot (WB): 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | HL1834 |
| Immunogen | Recombinant fragment of human CRALBP |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2938268 |
Product Specific Information
- Store as concentrated solution.
- Centrifuge briefly prior to opening vial.
Target Information
Cellular retinaldehyde-binding protein (CRALBP) plays an essential role in the regeneration of 11-cis-retinal used in rod visual pigments such as opsin and rhodopsin. Once 11-cis-retinal is photoisomerized in the rod outer segment, it is converted to all-trans-retinal and further modified into all-trans-retinol. All-trans-retinol then diffuses into the retinal pigment epithelium (RPE) to be converted back to 11-cis-retinol and further oxidized into 11-cis-retinal, both reactions mediated by CRALBP.
Genetic mutations affecting CRALBP function have been linked to visual diseases such as Bothnia dystrophy, retinitis punctata albescens, retinitis pigmentosa, and Newfoundland rod-cone dystrophy.
CRALBP presence serves as a marker for RPE and Müller glial cells of the retina.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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