Thermo Fisher Scientific LEPREL1 Polyclonal Antibody
Rabbit polyclonal antibody targeting human LEPREL1. Validated for IHC (paraffin) with 1:50–1:200 dilution. Recombinant protein immunogen, purified by antigen affinity chromatography. Supplied in PBS with 40% glycerol and 0.02% sodium azide. For researc...
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human LEPREL1 (amino acids 177–288). Recombinant protein control fragment (Product #RP-89684). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2643345 |
Product Specific Information
Immunogen sequence:
ANPEHMEMQQ NIENYRATAG VEALQLVDRE AKPHMESYNA GVKHYEADDF EMAIRHFEQA LREYFVEDTE CRTLCEGPQR FEEYEYLGYK AGLYEAIADH YMQVLVCQHE CV
Highest antigen sequence identity to the following orthologs:
- Mouse: 86%
- Rat: 86%
Target Information
This gene encodes a member of the prolyl 3-hydroxylase subfamily of 2-oxo-glutarate-dependent dioxygenases. These enzymes play a critical role in collagen chain assembly, stability, and cross-linking by catalyzing post-translational 3-hydroxylation of proline residues. Mutations in this gene are associated with nonsyndromic severe myopia with cataract and vitreoretinal degeneration. Downregulation of this gene may play a role in breast cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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