Thermo Fisher Scientific Thyroglobulin (Thyroidal Cell Marker) Monoclonal Antibody (SPM221)
Thyroglobulin 단백질을 인식하는 SPM221 클론의 단일클론 항체로, 인간·마우스·랫트 반응성을 가짐. Western blot, IHC, Flow cytometry, ELISA 등 다양한 응용 가능. 단백질 A/G로 정제된 액상 형태이며, 연구용으로만 사용.
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Thermo Fisher Scientific Thyroglobulin (Thyroidal Cell Marker) Monoclonal Antibody (SPM221)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
| ELISA | Assay-dependent |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SPM221 |
| Immunogen | Human thyroid follicular cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Target Information
Human thyroglobulin (hTg) is a high molecular weight glycoprotein (605 kDa) found in thyroid follicular cells. It plays a central role in the uptake, incorporation, and regulated biosynthesis of thyroid hormones T4 and T3. Thyroid disorders are largely autoimmune in origin, and anti-thyroglobulin autoantibodies were the first to be discovered. Anti-hTG is found in all thyroid autoimmune diseases (e.g., Hashimoto thyroiditis, Graves disease), with the highest levels observed in Hashimoto thyroiditis. Anti-hTG is also associated with thyroid cancer and can be used for patient follow-up.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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