Thermo Fisher Scientific UBASH3A Monoclonal Antibody (OTI5F10), TrueMAB
Human UBASH3A 단백질(aa 288-549)을 인식하는 Mouse IgG1 단클론 항체로 Western blot에 최적화됨. 1 mg/mL 농도의 액상 제품이며, PBS/BSA/glycerol 버퍼에 보존. -20°C에서 보관, 반복 동결/해동은 피할 것.
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Applications
- Western Blot (WB): Tested dilution 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5F10 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 288–549 of human UBASH3A produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
TULA (T cell ubiquitin ligand, UBASH3A, ubiquitin associated and SH3 domain containing A), also known as STS-2 or CLIP4, is a 661 amino acid protein localized to both the nucleus and cytoplasm. It contains one SH3 domain and one UBA domain and is highly expressed in thymus, bone marrow, spleen, and peripheral blood leukocytes.
TULA forms homodimers or homo-oligomers that interfere with receptor-type tyrosine kinase degradation, promoting accumulation of activated receptors on the cell surface. It participates in an EGFR- and Cbl-containing complex that interacts with ubiquitinated proteins.
The gene encoding TULA maps to human chromosome 21 and may be involved in the pathogenesis of type I diabetes. Multiple isoforms are produced via alternative splicing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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