Thermo Fisher Scientific UBASH3A Monoclonal Antibody (OTI4H1), TrueMAB

Applications

• Western Blot (WB): Tested dilution 1:2,000

Product Specifications

Target Information

TULA (T cell ubiquitin ligand, UBASH3A, ubiquitin associated and SH3 domain containing A), also known as STS-2 or CLIP4, is a 661 amino acid protein that localizes to both the nucleus and cytoplasm. It contains one SH3 domain and one UBA domain, and is expressed at high levels in thymus, bone marrow, spleen, and peripheral blood leukocytes. TULA exists as a homodimer or homo-oligomer that interferes with degradation of receptor-type tyrosine kinases, promoting accumulation of activated receptors on the cell surface. It forms part of an EGFR- and Cbl-containing complex that interacts with ubiquitinated proteins. The gene encoding TULA, located on human chromosome 21, may be involved in the pathogenesis of type I diabetes. Multiple isoforms are produced due to alternative splicing.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.