Thermo Fisher Scientific GPR26 Polyclonal Antibody
Thermo Fisher Scientific의 GPR26 Polyclonal Antibody는 인간 및 다양한 종에 반응하는 토끼 유래 IgG 항체입니다. 항원 친화 크로마토그래피로 정제되었으며, IHC(P)에서 2.2 µg/mL로 검증되었습니다. 뇌 특이적 GPR26 단백질 연구에 적합하며, 장기 보관 시 -20°C에서 안정적으로 유지됩니다.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 2.2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Dog, Horse, Human, Non-human primate, Pig |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 17 amino acid peptide from 2nd extracellular domain of human GPR26 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551061 |
Product Specific Information
Percent identity with other species by BLAST analysis:
Human, Gibbon, Monkey, Marmoset, Elephant, Panda, Dog, Horse, Pig (100%)
Mouse, Rat, Rabbit (94%)
Target Information
The G-protein-coupled receptor (GPCR) superfamily is comprised of an estimated 600–1,000 members and is the largest known class of molecular targets with proven therapeutic value.
GPR26 is a brain-specific orphan GPCR with a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulates adenylate cyclase, resulting in an elevation of intracellular cAMP.
In the CNS, the highest GPR26 expression is in the amygdala, hippocampus, and thalamus. Weak expression is detected in testis.
GPR26 is down-regulated in glioblastoma. Depletion of GPR26 has been shown to increase fat storage in C. elegans, whereas GPR26 deficiency in the hypothalamus is associated with high genetic susceptibility to the onset of obesity in mice.
GPR26 deficiency also causes metabolic complications commonly associated with obesity, including glucose intolerance, hyperinsulinemia, and dyslipidemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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