Thermo Fisher Scientific GPR26 Polyclonal Antibody
Thermo Fisher Scientific의 GPR26 Polyclonal Antibody는 인간 및 다양한 종에서 반응성을 보이는 Rabbit IgG 기반 항체입니다. IHC(P) 등에 사용 가능하며, GPR26 단백질 연구에 적합합니다. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 안정성을 제공합니다.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 6–15 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Dog, Horse, Human, Non-human primate, Pig |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 18 amino acid peptide from 3rd cytoplasmic domain of human GPR26 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term; for long-term storage, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551060 |
Target Information
The G-protein-coupled receptor (GPCR) superfamily is comprised of an estimated 600–1,000 members and represents the largest known class of molecular targets with proven therapeutic value.
GPR26 is a brain-specific orphan GPCR with constitutive activity mediated by G(s)-alpha protein, stimulating adenylate cyclase and elevating intracellular cAMP levels.
In the CNS, GPR26 is highly expressed in the amygdala, hippocampus, and thalamus, with weak expression in testis. It is down-regulated in glioblastoma.
Research has shown that depletion of GPR26 increases fat storage in C. elegans, and deficiency in the hypothalamus correlates with genetic susceptibility to obesity in mice.
GPR26 deficiency also leads to metabolic complications such as glucose intolerance, hyperinsulinemia, and dyslipidemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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