Thermo Fisher Scientific TACC3 Monoclonal Antibody (OTI7B11), TrueMAB
TACC3 단백질을 인식하는 Mouse monoclonal antibody로, Western blot, IHC, ICC/IF, Flow cytometry에 사용 가능. Human 시료에 반응하며, 고순도 친화 크로마토그래피 정제. 안정적인 PBS/BSA/glycerol buffer에 보관되며 연구용으로 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI7B11 |
| Immunogen | Full length human recombinant protein of human TACC3 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.83 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
TACC1 is located on the 8p11 chromosomal region, which is amplified in approximately 15% of all breast tumor samples. The short arm of chromosome 8 also contains FGFR1, whose expression is enhanced in most breast cancer tumors.
TACC family members — TACC1, TACC2, and TACC3 — map closely to the corresponding FGFR1, FGFR2, and FGFR3 genes on chromosomes 4, 8, and 10, respectively. Since they are phylogenetically related, it is proposed that TACC and FGFR have similar roles in cell growth and differentiation.
TACC1 contains a conserved C-terminal region similar to the Drosophila homolog D-TACC. D-TACC is necessary for normal spindle function, and mammalian TACC proteins appear to interact with centrosomes and microtubules in a similar manner.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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