Thermo Fisher Scientific INT3 Polyclonal Antibody
Human 및 Mouse 시료에 반응하는 Rabbit Polyclonal INT3 항체. Western blot과 Immunoprecipitation에 적합하며, 항원 친화 크로마토그래피로 정제됨. 액상 형태로 제공되며 4°C에서 보관. Integrator complex 및 DNA 손상 복구 연구에 활용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 10 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 950 and 1,000 of human integrator complex subunit 3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Orangutan
Target Information
Component of the Integrator complex, which is involved in the transcription and 3′-box-dependent processing of small nuclear RNAs (snRNA) U1 and U2. The complex associates with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to U1 and U2 snRNA genes.
Also functions as part of the SOSS complex, a multiprotein complex acting downstream of the MRN complex to promote DNA repair and G2/M checkpoint control. The SOSS complex binds single-stranded DNA at lesions, facilitating cell-cycle checkpoint activation, recombinational repair, and genomic stability. INTS3 is essential for SOSS complex assembly and stabilization at DNA damage sites.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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