Thermo Fisher Scientific Patched1 Monoclonal Antibody (OTI1H8), TrueMAB
Human PTCH1 단백질(aa 770-1027)에 특이적인 마우스 단클론 항체로 Western blot에 적합. TrueMAB 포맷, carrier-free 형태로 제공. 재구성 후 1 mg/mL 농도 유지, 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:200
- Publications: 없음
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1H8 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 770–1027 of human PTCH1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
This gene encodes a member of the patched gene family. The encoded protein acts as the receptor for sonic hedgehog, desert hedgehog, and indian hedgehog proteins, which are involved in embryonic development and tumorigenesis.
PTCH1 functions as a tumor suppressor; mutations are associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinoma of the bladder, and holoprosencephaly.
Alternative splicing produces multiple transcript variants encoding different isoforms. Some splice variants have been described but their full sequences and biological validity remain uncertain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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