Thermo Fisher Scientific Ago2 Monoclonal Antibody (1B1)
Ago2 단백질을 인식하는 Thermo Fisher Scientific의 단일클론 항체로, 인간 시료에 반응합니다. Western blot 등 연구용 분석에 적합하며, 단백질 A로 정제된 동결건조 형태입니다. RNA 침묵 경로 연구 및 miRNA 관련 기전 분석에 유용합니다.
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- 70106-200UG
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Applications
- Western Blot (WB): Tested dilution 1–5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1B1 |
| Immunogen | Recombinant protein corresponding to the N-terminal aa 1–148 of human Ago2 |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.5–1.0 mg/mL |
| Purification | Protein A |
| Storage buffer | PBS, pH 7.4, with 1% BSA |
| Contains | No preservative |
| Storage conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitute in 100 µL of distilled water (final concentration 2 mg/mL) for stock solution.
Dilute the stock solution in 10 mM PBS, pH 7.4 + 1% BSA immediately before use.
Target Information
Ago proteins are broadly expressed in somatic cells and associate with miRNAs, playing key roles in RNA silencing pathways.
Among them, Ago2 uniquely exhibits endonucleolytic “Slicer” activity, enabling miRNA-directed cleavage of target mRNA when base-pairing is perfect.
With partial complementarity, Ago2 represses translation instead of cleavage.
Ago2 is essential in RNA interference, translation repression, and heterochromatin formation, acting as a core element of the RISC complex.
It also functions in Dicer-independent RNA slicing and miRNA maturation regulation.
Over-expression of Ago2 is linked to tumor growth and patient survival, and gene disruption in mice shows its necessity in embryonic and hematopoietic development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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