Thermo Fisher Scientific COMT Polyclonal Antibody
Rabbit Polyclonal COMT 항체로 Western blot 및 Immunoprecipitation에 적합. 인간 COMT(aa 42-221) 재조합 단백질 면역원 사용. 세포막 및 세포질 위치 단백질 검출에 유용. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunoprecipitation (IP) | 1:50–1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 42–221 of human COMT (NP_009294.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.43 mg/mL |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2805189 |
Product Specific Information
Immunogen sequence:
VGDKKGKIVD AVIQEHQPSV LLELGAYCGY SAVRMARLLS PGARLITIEI NPDCAAITQR MVDFAGVKDK VTLVVGASQD IIPQLKKKYD VDTLDMVFLD HWKDRYLPDT LLLEECGLLR KGTVLLADNV ICPGAPDFLA HVRGSSCFEC THYQSFLEYR EVVDGLEKAI YKGPGSEAGP
Positive Samples: MCF-7, HT-29, THP-1, A-431, HepG2, Mouse liver
Cellular Location: Cell membrane, Cytoplasm, Extracellular side, Single-pass type II membrane protein
Target Information
Catechol-O-methyltransferase (COMT) catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including dopamine, epinephrine, and norepinephrine. This O-methylation is a major degradative pathway of catecholamine neurotransmitters. COMT also metabolizes catechol drugs used in treating hypertension, asthma, and Parkinson’s disease.
COMT exists in two forms: soluble (S-COMT) and membrane-bound (MB-COMT), differing at the N-terminus. Several transcript variants arise from alternative translation initiation sites and promoters.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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