Thermo Fisher Scientific Kir2.1 (KCNJ2) Polyclonal Antibody
Kir2.1(KCNJ2) 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ELISA에 사용 가능. Human, Mouse, Rat 반응성. 고순도 Affinity 정제, 1.72 mg/mL 농도. -20°C 보관, 연구용 전용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 318–427 of human KCNJ2 (NP_0008821) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.72 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2805194 |
Product Specific Information
- Immunogen sequence:
NEILWGHRYE PVLFEEKHYY KVDYSRFHKT YEVPNTPLCS ARDLAEKKYI LSNANSFCYE NEVALTSKEE DDSENGVPES TSTDTPPDID LHNQASVPLE PRPLRRESEI - Positive Samples: A-549, Mouse heart, Rat heart
- Cellular Location: Lipid-anchor, Membrane, Multi-pass membrane protein
Target Information
The KIR2 subunit family includes 2.1, 2.2, 2.3, and 2.4. Unlike G protein-coupled KIR3 subunits, KIR2.1 requires both phosphorylation by PKA and ATP hydrolysis for functional activity.
KIR2.1 is expressed in the superior and inferior collicula and the pontine region of the brain, moderating synaptic transmission.
In the placenta, KIR2.1 is expressed throughout gestation in cytotrophoblast cells. In the kidney, KIR2.1 colocalizes with KIR5.1 in the proximal tubule.
KIR2.1, 2.2, and 2.3 associate with the membrane-associated guanylate kinase synapse-associated protein 97 (SAP97) in the cerebellum and heart.
Phosphorylation of KIR2.2 by protein kinase A inhibits its association with SAP97.
주의사항
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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