Thermo Fisher Scientific CD61 (Integrin beta 3) Monoclonal Antibody (VI-PL2), Super Bright 436, eBioscience
CD61(Integrin β3)을 인식하는 VI-PL2 단클론 항체로, Super Bright 436 형광체가 결합된 Flow Cytometry용 항체입니다. 인간 및 비인간 영장류, 개 시료에 반응하며 혈소판 응집 및 세포 부착 연구에 적합합니다. 4°C 암소 보관, 동결 금지.
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Applications and Tested Dilution
- Application: Flow Cytometry (Flow)
- Tested Dilution: 5 µL (1.0 µg)/test
- Publications: View 3 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Baboon, Dog, Cynomolgus monkey, Human, Rhesus monkey |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), Super Bright™ 436, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | VI-PL2 |
| Conjugate | Super Bright™ 436 |
| Excitation / Emission Max | 413 / 431 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2784812 |
Available Formats:
- Unconjugated
- APC
- APC-eFluor 780
- FITC
- PE
- PerCP-eFluor 710
- Super Bright 645
- Request custom conjugation
Product Specific Information
The VI-PL2 monoclonal antibody reacts with human CD61 (Integrin beta 3, GPIIIa).
CD61 (90–110 kDa) is a β-integrin family member expressed on leukocytes, platelets, endothelial, and smooth muscle cells. It forms heterodimers with α-integrins CD41 (αIIb) and CD51 (αv), mediating adhesion, trafficking, proliferation, and differentiation.
- CD41/CD61 (αIIbβ3): Involved in platelet aggregation; binds fibrinogen, vWF, and fibronectin.
- CD51/CD61 (αvβ3): Binds vitronectin, fibronectin, vWF, and fibrinogen; modulates endothelial migration and survival.
This antibody cross-reacts with canine and non-human primates (baboon, rhesus, cynomolgus monkey).
Applications Reported: Flow cytometric analysis
Applications Tested: Pre-diluted and tested on human peripheral blood cells. Use 5 µL (1.0 µg) per test (in 100 µL final volume).
Fluorochrome Information:
- Excitation: 405 nm
- Emission: 436 nm
- Recommended filter: 450/50 bandpass
- Use Super Bright Complete Staining Buffer (Product # SB-4401) when combining multiple Super Bright conjugates.
Super Bright Polymer Dyes are sold under license from Becton, Dickinson and Company.
Target Information
CD61 (GPIIIa, ITGB3) is a 105 kDa glycoprotein expressed on megakaryocytes, platelets, and their precursors. It associates with αIIb (CD41) or αV (CD51) integrins and functions as a receptor for fibrinogen, fibronectin, von Willebrand factor, vitronectin, and thrombospondin.
- Participates in platelet aggregation and cell adhesion
- Involved in cell-surface signaling
- Associated diseases: Glanzmann Thrombasthenia, Platelet type-16 Bleeding Disorder
For Research Use Only. Not for use in diagnostic procedures. Not for resale without authorization.
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