Thermo Fisher Scientific Connexin 43 Polyclonal Antibody
Connexin 43 단백질을 인식하는 염소 폴리클로날 항체로, Western blot 및 IHC에 사용 가능. 인간과 랫드에 반응하며, 합성 펩타이드 면역원으로 제작됨. 0.5 mg/mL 농도의 액상 형태로, BSA와 sodium azide를 포함한 TBS 버퍼에 보관. -20°C에서 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.1–1 µg/mL | - |
| Immunohistochemistry (IHC) | – | 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Published Species | Sheep |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (QPFDFPDDNQNSKK) corresponding to internal amino acids 333–346 of GJA1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10987137 |
Product Specific Information
- Predicted to react with canine, human, and porcine species based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 1:32,000.
Target Information
Connexin 43 (Cx43) is a member of the gap junction protein family. Connexins assemble as hexamers and form hemichannels that align with those on adjacent cells to create intercellular channels, facilitating direct cell-to-cell communication. These gap junctions play essential roles in development, cell growth regulation, and cardiac function. Phosphorylation of Cx43, particularly at Ser368 by protein kinase C (PKC), modulates gap junction assembly and communication. Src kinase can also phosphorylate Cx43, influencing its activity. Cx43 is the predominant connexin in the heart, contributing to synchronized contraction and embryonic development. A related pseudogene, GJA1P, is located on chromosome 5. Mutations in the GFAP gene are associated with various inherited disorders including Charcot-Marie-Tooth disease, oculodentodigital dysplasia, and heart malformations. Alternatively spliced transcript variants of GFAP have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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