Thermo Fisher Scientific Connexin 43 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Predicted to react with canine, human, and porcine species based on sequence homology.
• Tested in Peptide ELISA: antibody detection limit dilution 1:32,000.

Target Information

Connexin 43 (Cx43) is a member of the gap junction protein family. Connexins assemble as hexamers and form hemichannels that align with those on adjacent cells to create intercellular channels, facilitating direct cell-to-cell communication. These gap junctions play essential roles in development, cell growth regulation, and cardiac function. Phosphorylation of Cx43, particularly at Ser368 by protein kinase C (PKC), modulates gap junction assembly and communication. Src kinase can also phosphorylate Cx43, influencing its activity. Cx43 is the predominant connexin in the heart, contributing to synchronized contraction and embryonic development. A related pseudogene, GJA1P, is located on chromosome 5. Mutations in the GFAP gene are associated with various inherited disorders including Charcot-Marie-Tooth disease, oculodentodigital dysplasia, and heart malformations. Alternatively spliced transcript variants of GFAP have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.