Thermo Fisher Scientific FLT4 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunocytochemistry (ICC/IF)

1:50-1:200

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1174-1363 of human VEGFR3/FLT4 (NP_8915552) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:VEGF Receptor 3,uniProtId:P35916-2,ncbiNodeId:9606,antigenRange:1174-1363,antigenLength:1363,antigenImageFileName:PA5-109731_VEGF_Receptor_3_P35916-2_Rabbit.svg,antigenImageFileNamePDP:PA5-109731_VEGF_Receptor_3_P35916-2_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.99 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2855142

Product Specific Information

Immunogen sequence: QGRGLQEEEE VCMAPRSSQS SEEGSFSQVS TMALHIAQAD AEDSPPSLQR HSLAARYYNW VSFPGCLARG AETRGSSRMK TFEEFPMTPT TYKGSVDNQT DSGMVLASEE FEQIESRHRQ ESGFSCKGPG QNVAVTRAHP DSQGRRRRPE RGARGGQVFY NSEYGELSEP SEEDHCSPSA RVTFFTDNSY

Target Information

Vascular endothelial growth factor is a key regulator of blood vessel development in embryos and angiogenesis in adult tissues. Unlike VEGF, the related VEGFC stimulates the growth of lymphatic vessels through its specificl ymphatic endothelial receptor VEGFR-3. In 1998, Dumont showed that targeted inactivation of the VEGFR-3 gene in mice resulted in defective blood vessel development in early embryos. Vasculogenesis and angiogenesis occurred, but large vessels became abnormally organized with defective lumens, leading to fluid accumulation in the pericardial cavity and cardiovascular failure at embryonic day 9.5. Thus, VEGFR3 has an essential role in the development of theembryonic cardiovascular system before the emergence of the lymphatic vessels.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.